Mutations affecting the superantigen activity of staphylococcal enterotoxin B
نویسندگان
چکیده
منابع مشابه
Mutations defining functional regions of the superantigen staphylococcal enterotoxin B
Staphylococcal enterotoxin B (SEB) is both a superantigen and toxin. As a superantigen, SEB can bind to major histocompatibility complex (MHC) class II molecules to form a ligand for alpha/beta T cell receptors bearing particular V beta elements. As a toxin, SEB causes rapid weight loss in mice sometimes leading to death. We show here that both of these functions map to the NH2-terminal portion...
متن کاملMutations Defining Functional Regions of the Superantigen Staphylococcal Enterotoxin
Staphylococcal enterotoxin B (SEB) is both a superantigen and toxin. As a superantigen, SEB can bind to major histocompatibility complex (MHC) class II molecules to form a ligand for ot/B T cell receptors bearing particular VB elements. As a toxin, SEB causes rapid weight loss in mice sometimes leading to death. We show here that both of these functions map to the NH2-terminal portion of the to...
متن کاملMutations Defining Functional Regions of the Superantigen Staphylococcal Enterotoxin B By
Staphylococcal enterotoxin B (SEB) is both a superantigen and toxin. As a superantigen, SEB can bind to major histocompatibility complex (MHC) class II molecules to form a ligand for ot/B T cell receptors bearing particular VB elements. As a toxin, SEB causes rapid weight loss in mice sometimes leading to death. We show here that both of these functions map to the NH2-terminal portion of the to...
متن کاملProtection against bacterial superantigen staphylococcal enterotoxin B by passive vaccination.
We investigated the ability of two overlapping fragments of staphylococcal enterotoxin B (SEB), which encompass the whole toxin, to induce protection and also examined if passive transfer of chicken anti-SEB antibodies raised against the holotoxin could protect rhesus monkeys against aerosolized SEB. Although both fragments of SEB were highly immunogenic, the fragments failed to protect mice wh...
متن کاملStructure of the staphylococcal enterotoxin B vaccine candidate S19 showing eliminated superantigen activity
Four mutations (N23A, Y90A, R110A and F177A) were introduced into S19, a vaccine candidate for staphylococcal enterotoxin B (SEB), resulting in a lower binding affinity towards the T-cell receptor beta chain (TCB) and reducing its superantigen activity. The structure of S19 was solved and was superposed on the native or complex structure of SEB. In the superposition model, mutations that were i...
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ژورنال
عنوان ژورنال: Immunology
سال: 1997
ISSN: 0019-2805,1365-2567
DOI: 10.1046/j.1365-2567.1997.00151.x